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FLASH GENE

Symbol

TBC1D10A

contributors: mct/npt - updated : 16-06-2017

HGNC name	TBC1 domain family, member 10A
HGNC id	23609

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031937 9 - 2017 NP_114143 57.1 508 - 2008 1845075 NM_001204240 9 - 2038 NP_001191169 - 515 - 2008 1845075

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine placenta       highly Lymphoid/Immune spleen       highly Nervous brain         Reproductive female system ovary         female system breast mammary gland   highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal Tre-2/Bub2/Cdc16 (TBC) domain that stabilizes active ARF6, has RabGAP activity, and is required for the accumulation of vacuoles
	a PDZ domain

HOMOLOGY

interspecies

homolog to murine Tbc1d10

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

basic FUNCTION	PDZ-domain binding activity
	TBC domain-containing protein that regulates microvillar subdomains and structure
	GTPase-activating protein specific for RAB27A
	TBC1D10A, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
	apical microvillar protein, regulating ARF6-dependent membrane trafficking
	regulates membrane trafficking both by stabilizing ARF6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing RAB8A-GTP levels
	TBC1D10A, CYTH2 regulate endocytosis at distinct stages
	TBC1D10A, TBC1D10B, TBC1D10C, having the physiological and pathological functions such as melanosome transport, exosome secretion, and T-cell activation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds the PDZ domains of SLC9A3R1, which binds ezrin, a major actin-binding protein of microvilli
	TBC1D10A interacts with SYTL1 to coordinate RAB8A and ARF6 membrane trafficking
	peripheral CYTH2 recruits TBC1D10A to the same area and the interaction requires glucose-induced endocytosis in pancreatic beta-cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS