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FLASH GENE
Symbol TBC1D10A contributors: mct/npt - updated : 16-06-2017
HGNC name TBC1 domain family, member 10A
HGNC id 23609
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineplacenta   highly
Lymphoid/Immunespleen   highly
Nervousbrain    
Reproductivefemale systemovary   
 female systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal Tre-2/Bub2/Cdc16 (TBC) domain that stabilizes active ARF6, has RabGAP activity, and is required for the accumulation of vacuoles
  • a PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Tbc1d10
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • PDZ-domain binding activity
  • TBC domain-containing protein that regulates microvillar subdomains and structure
  • GTPase-activating protein specific for RAB27A
  • TBC1D10A, TBC1D10C regulate exosome secretion in a catalytic activity-dependent manner
  • apical microvillar protein, regulating ARF6-dependent membrane trafficking
  • regulates membrane trafficking both by stabilizing ARF6-GTP and by inhibiting the recycling of membrane through the tubular endosome by decreasing RAB8A-GTP levels
  • TBC1D10A, CYTH2 regulate endocytosis at distinct stages
  • TBC1D10A, TBC1D10B, TBC1D10C, having the physiological and pathological functions such as melanosome transport, exosome secretion, and T-cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds the PDZ domains of SLC9A3R1, which binds ezrin, a major actin-binding protein of microvilli
  • TBC1D10A interacts with SYTL1 to coordinate RAB8A and ARF6 membrane trafficking
  • peripheral CYTH2 recruits TBC1D10A to the same area and the interaction requires glucose-induced endocytosis in pancreatic beta-cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS