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FLASH GENE
Symbol CCT7 contributors: npt/ - updated : 18-06-2004
HGNC name chaperonin containing TCP1, subunit 7 (eta)
HGNC id 1622
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cct7
homolog to rattus LOC297406
Homologene
FAMILY
  • TCP-1 chaperonin family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • soluble guanylyl cyclase-interacting protein, that assist the folding of proteins upon ATP hydrolysis
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with GUCY1A2 and GUCY1B2 (in cooperation with some other factor, inhibits its activity by modifying the binding of Nitric oxide to the heme group or the subsequent conformational changes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS