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FLASH GENE

Symbol

CCT7

contributors: npt/ - updated : 18-06-2004

HGNC name	chaperonin containing TCP1, subunit 7 (eta)
HGNC id	1622

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p13.2      Physical location : 73.461.363 - 73.480.149
Synonym name	chaperonin containing t-complex polypeptide 1, eta subunit
	HIV-1 Nef interacting protein
	T-complex protein 1, eta subunit
Synonym symbol(s)	Ccth, Nip7-1, CCT-ETA, MGC110985, TCP-1-eta

DNA

TYPE	functioning gene
STRUCTURE	18.74 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006429 12 - 1948 NP_006420 - 543 - Guo (2005) NM_001009570 7 - 1336 NP_001009570 - 339 - Guo (2005) NM_001166284 - - 1687 NP_001159756 - 456 - Guo (2005)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine adrenal gland       highly Reproductive female system uterus cervix   highly   male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Cct7
	homolog to rattus LOC297406

Homologene

FAMILY

TCP-1 chaperonin family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	soluble guanylyl cyclase-interacting protein, that assist the folding of proteins upon ATP hydrolysis
	decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
	required for maturation of sphingosine kinase 1 (Zebol 2009)
	CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

interacting with GUCY1A2 and GUCY1B2 (in cooperation with some other factor, inhibits its activity by modifying the binding of Nitric oxide to the heme group or the subsequent conformational changes)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS