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FLASH GENE
Symbol CCT7 contributors: npt/ - updated : 18-06-2004
HGNC name chaperonin containing TCP1, subunit 7 (eta)
HGNC id 1622
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineadrenal gland   highly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cct7
homolog to rattus LOC297406
Homologene
FAMILY
  • TCP-1 chaperonin family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • soluble guanylyl cyclase-interacting protein, that assist the folding of proteins upon ATP hydrolysis
  • decreases concomitantly with the reduction of chaperone activity during cell cycle arrest at M phase
  • required for maturation of sphingosine kinase 1 (Zebol 2009)
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin (Kabir 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • eight subunits that assists in the folding of actin, tubulin and other cytosolic proteins
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • interacting with GUCY1A2 and GUCY1B2 (in cooperation with some other factor, inhibits its activity by modifying the binding of Nitric oxide to the heme group or the subsequent conformational changes)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS