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FLASH GENE
Symbol MIEN1 contributors: mct - updated : 24-05-2012
HGNC name migration and invasion enhancer 1
HGNC id 28230
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a thioredoxin-like fold
  • a conserved CxxC or CxxU (U is Sec) motif
  • a functional CAAX motif (is post-translationally modified by PGGT1B)
  • HOMOLOGY
    Homologene
    FAMILY
  • RDX family
  • SelWTH family (selenoprotein SELV, SELT, SELH)
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • cysteine-containing protein that may have a redox function
  • acts as a signaling molecule channeling signaling through PI3K/Akt pathway
  • possible role in metastatic dissemination of cancer cells
  • can use catalytic cysteine (or Sec) to form transient mixed disulfides with substrate proteins
  • acts as a signalling molecule that increases invasive potential of prostate cancer cells by NF-KappaB-mediated downstream target gene
  • functionally enhances migration and invasion of tumor cells and is an important target for cancer therapy
  • prenylation is required for its function in cancer cells and imply that the post-translational modification may functionally regulate metastatic progression of disease
  • role in the migration and metastatic dissemination of cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with glutathione peroxidase 1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in infiltrating ductal carcinomas of the breast
    tumoral     --over  
  • abundantly expressed in breast cancer, expression positively correlating with grade and stage of cancer progression
  • tumoral     --over  
    in the higher grades of prostate adenocarcinoma compared with low expression in normal or benign prostatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene biomarker and/or a target for development of broadly applicable cancer-specific therapies
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    important target for cancer therapy, since the over expression of MIEN1 functionally enhances migration and invasion of tumor cells
    ANIMAL & CELL MODELS