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FLASH GENE
Symbol MIEN1 contributors: mct - updated : 24-05-2012
HGNC name migration and invasion enhancer 1
HGNC id 28230
Location 17q12      Physical location : -
Genatlas name redox protein 12KD
Synonym name
  • hypothetical protein LOC84299
  • HBV X-transactivated gene 4 protein
  • protein C35
  • chromosome 17 open reading frame 37
  • Synonym symbol(s) C35, ORB3, XTP4, C17orf37, MGC14832, RDX12
    DNA
    TYPE functioning gene
    STRUCTURE 1.38 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located located in the ERBB2 amplicon
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 781 12.27 115 - 2007 17503775
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Respiratory     
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a thioredoxin-like fold
  • a conserved CxxC or CxxU (U is Sec) motif
  • a functional CAAX motif (is post-translationally modified by PGGT1B)
  • HOMOLOGY
    Homologene
    FAMILY
  • RDX family
  • SelWTH family (selenoprotein SELV, SELT, SELH)
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • cysteine-containing protein that may have a redox function
  • acts as a signaling molecule channeling signaling through PI3K/Akt pathway
  • possible role in metastatic dissemination of cancer cells
  • can use catalytic cysteine (or Sec) to form transient mixed disulfides with substrate proteins
  • acts as a signalling molecule that increases invasive potential of prostate cancer cells by NF-KappaB-mediated downstream target gene
  • functionally enhances migration and invasion of tumor cells and is an important target for cancer therapy
  • prenylation is required for its function in cancer cells and imply that the post-translational modification may functionally regulate metastatic progression of disease
  • role in the migration and metastatic dissemination of cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with glutathione peroxidase 1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in infiltrating ductal carcinomas of the breast
    tumoral     --over  
  • abundantly expressed in breast cancer, expression positively correlating with grade and stage of cancer progression
  • tumoral     --over  
    in the higher grades of prostate adenocarcinoma compared with low expression in normal or benign prostatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene biomarker and/or a target for development of broadly applicable cancer-specific therapies
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    important target for cancer therapy, since the over expression of MIEN1 functionally enhances migration and invasion of tumor cells
    ANIMAL & CELL MODELS