Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PDYN contributors: mct - updated : 30-03-2015
HGNC name prodynorphin
HGNC id 8820
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal six conserved cysteines
  • HOMOLOGY
    interspecies homolog to murine Pdyn
    Homologene
    FAMILY
  • opioids neuropeptides precursors family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text translocation across the plasma membrane may represent a previously unknown mechanism by which dynorphins can signal information to the cell interior
    basic FUNCTION
  • playing a role in Alzheimer disease neuropathology
  • induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors
  • essential role of dynorphin in the termination of seizures
  • activates bradykinin receptors to maintain neuropathic pain
  • regulate pain processing and modulate the rewarding effects of addictive substances
  • acts as a neuromodulator to inhibit ITCH in the dorsal horn of the spinal cord
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between OPRK1 and its native peptide ligand PDYN
  • REST represses PDYN expression in neuroblastoma cells and the adult human brain and may have implications for mental health and brain/mental disorders
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA23
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    occurring during aging and AD may mediate cognitive deficits by altering the glutamatergic system integrity
    Susceptibility
  • to alcohol dependence
  • to opioid addiction
  • to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • Variant & Polymorphism repeat , other
  • allelic variation at the promoter contributing to prtection against cocaine dependence
  • polymorphisms increasing alcohol dependence
  • functional allelic variants in the PDYN promoter might modify the risk to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • polymorphisms in PDYN are associated with opioid addiction
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention
    ANIMAL & CELL MODELS