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FLASH GENE
Symbol PDYN contributors: mct - updated : 30-03-2015
HGNC name prodynorphin
HGNC id 8820
ASSOCIATED DISORDERS
corresponding disease(s) SCA23
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
occurring during aging and AD may mediate cognitive deficits by altering the glutamatergic system integrity
Susceptibility
  • to alcohol dependence
  • to opioid addiction
  • to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • Variant & Polymorphism repeat , other
  • allelic variation at the promoter contributing to prtection against cocaine dependence
  • polymorphisms increasing alcohol dependence
  • functional allelic variants in the PDYN promoter might modify the risk to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • polymorphisms in PDYN are associated with opioid addiction
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention
    ANIMAL & CELL MODELS