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FLASH GENE
Symbol PDYN contributors: mct - updated : 30-03-2015
HGNC name prodynorphin
HGNC id 8820
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum highly Homo sapiens
Reproductivemale systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal six conserved cysteines
  • HOMOLOGY
    interspecies homolog to murine Pdyn
    Homologene
    FAMILY
  • opioids neuropeptides precursors family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text translocation across the plasma membrane may represent a previously unknown mechanism by which dynorphins can signal information to the cell interior
    basic FUNCTION
  • playing a role in Alzheimer disease neuropathology
  • induces calcium influx via voltage-sensitive calcium channels in sensory neurons by activating bradykinin receptors
  • essential role of dynorphin in the termination of seizures
  • activates bradykinin receptors to maintain neuropathic pain
  • regulate pain processing and modulate the rewarding effects of addictive substances
  • acts as a neuromodulator to inhibit ITCH in the dorsal horn of the spinal cord
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between OPRK1 and its native peptide ligand PDYN
  • REST represses PDYN expression in neuroblastoma cells and the adult human brain and may have implications for mental health and brain/mental disorders
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA23
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    occurring during aging and AD may mediate cognitive deficits by altering the glutamatergic system integrity
    Susceptibility
  • to alcohol dependence
  • to opioid addiction
  • to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • Variant & Polymorphism repeat , other
  • allelic variation at the promoter contributing to prtection against cocaine dependence
  • polymorphisms increasing alcohol dependence
  • functional allelic variants in the PDYN promoter might modify the risk to develop Temporal Lobe Epilepsy (TLE) in subjects with familial predisposition
  • polymorphisms in PDYN are associated with opioid addiction
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneouspain 
    mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention
    ANIMAL & CELL MODELS