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FLASH GENE
Symbol KCMF1 contributors: mct - updated : 02-10-2010
HGNC name potassium channel modulatory factor 1
HGNC id 20589
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two N-terminal zinc-finger domains :
  • ZZ-type encoded by exons 1 and 2
  • a C2H2 type encoded by exon 3
  • zinc finger motif, a novel RING finger module at the N-terminal conserved region, which is rich in cysteine and histidine
  • a coiled-coil domain (encoded by exon 6)
  • C-terminal proline-rich region
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Loc297342
    Homologene
    FAMILY
  • KCMF1 family
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • early gene up-regulated during growth factor-induced branching tubulogenesis
  • having intrinsic E3 ubiquitin ligase activity and promoting ubiquitination
  • potential metastasis suppressor gene downregulated by high constitutive CD99 expression in Ewing's sarcoma cells
  • mediating pro-oncogenic functions
  • enhances proliferation, migration and invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    in preneoplastic lesions and in several epithelial malignancies, such as pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS