Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KCMF1

contributors: mct - updated : 02-10-2010

HGNC name	potassium channel modulatory factor 1
HGNC id	20589

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020122 7 - 7555 NP_064507 42 381 - 2010 PMID: 204733

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine acinar gland         pharynx       highly Endocrine thyroid       highly Respiratory respiratory tract larynx     highly

cells

System Cell Pubmed Species Stage Rna symbol Digestive acinar

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed during embryonic development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N-terminal zinc-finger domains :
	ZZ-type encoded by exons 1 and 2
	a C2H2 type encoded by exon 3
	zinc finger motif, a novel RING finger module at the N-terminal conserved region, which is rich in cysteine and histidine
	a coiled-coil domain (encoded by exon 6)
	C-terminal proline-rich region

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to rattus Loc297342

Homologene

FAMILY

KCMF1 family

CATEGORY

transcription factor , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	early gene up-regulated during growth factor-induced branching tubulogenesis
	having intrinsic E3 ubiquitin ligase activity and promoting ubiquitination
	potential metastasis suppressor gene downregulated by high constitutive CD99 expression in Ewing's sarcoma cells
	mediating pro-oncogenic functions
	enhances proliferation, migration and invasion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+ binding

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer tumoral     --over   in preneoplastic lesions and in several epithelial malignancies, such as pancreatic cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS