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FLASH GENE
Symbol KCMF1 contributors: mct - updated : 02-10-2010
HGNC name potassium channel modulatory factor 1
HGNC id 20589
Location 2p11.2      Physical location : 85.198.230 - 85.286.594
Synonym name
  • zinc finger, ZZ domain containing 1
  • differentially expressed in branching tubulogenesis 91
  • FGF-induced in gastric cancer
  • FGF-induced ubiquitin-protein ligase in gastric cancers
    • Synonym symbol(s) DEBT91, PCMF, ZZZ1, FIGC, DKFZP434L1021, FIGC
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 88.38 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 7555 42 381 - 2010 PMID: 204733
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrineacinar gland   
     pharynx   highly
    Endocrinethyroid   highly
    Respiratoryrespiratory tractlarynx  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveacinar
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text expressed during embryonic development
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		two N-terminal zinc-finger domains :
  • ZZ-type encoded by exons 1 and 2
  • a C2H2 type encoded by exon 3
  • zinc finger motif, a novel RING finger module at the N-terminal conserved region, which is rich in cysteine and histidine
  • a coiled-coil domain (encoded by exon 6)
  • C-terminal proline-rich region
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Loc297342
    Homologene
    FAMILY
  • KCMF1 family
    • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • early gene up-regulated during growth factor-induced branching tubulogenesis
  • having intrinsic E3 ubiquitin ligase activity and promoting ubiquitination
  • potential metastasis suppressor gene downregulated by high constitutive CD99 expression in Ewing's sarcoma cells
  • mediating pro-oncogenic functions
  • enhances proliferation, migration and invasion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ binding
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    in preneoplastic lesions and in several epithelial malignancies, such as pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS