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FLASH GENE
Symbol MED20 contributors: mct/ - updated : 19-12-2007
HGNC name mediator complex subunit 20
HGNC id 16840
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC316209
homolog to murine Usp49
Homologene
FAMILY
  • Mediator complex subunit 20 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may regulate transcription of class II genes through its association with RNA polymerase II-SRB complex (DNA dependent activity)
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • MED20 and MAF1 function in parallel pathways to negatively regulate ribosomal protein mRNA and tRNA synthesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase II binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS