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FLASH GENE
Symbol MED20 contributors: mct/ - updated : 19-12-2007
HGNC name mediator complex subunit 20
HGNC id 16840
Location 6p21.1      Physical location : 41.873.092 - 41.888.877
Synonym name
  • Trf (TATA binding protein-related factor)-proximal homolog (Drosophila)
  • ubiquitin specific protease 49
  • mediator of RNA polymerase II transcription subunit 20
  • Synonym symbol(s) PRO0213, USP49, TRFP, MGC29869, DKFZp586D2223
    DNA
    TYPE functioning gene
    STRUCTURE 15.79 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2478 - 212 - 2004 15175163
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     mouthtongue  highly
     salivary gland   highly
    Lymphoid/Immunespleen    
    Reproductivefemale systemuteruscervix  
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus LOC316209
    homolog to murine Usp49
    Homologene
    FAMILY
  • Mediator complex subunit 20 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may regulate transcription of class II genes through its association with RNA polymerase II-SRB complex (DNA dependent activity)
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • MED20 and MAF1 function in parallel pathways to negatively regulate ribosomal protein mRNA and tRNA synthesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase II binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS