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FLASH GENE
Symbol MED20 contributors: mct/ - updated : 19-12-2007
HGNC name mediator complex subunit 20
HGNC id 16840
DNA
TYPE functioning gene
STRUCTURE 15.79 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2478 - 212 - 2004 15175163
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 mouthtongue  highly
 salivary gland   highly
Lymphoid/Immunespleen    
Reproductivefemale systemuteruscervix  
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC316209
homolog to murine Usp49
Homologene
FAMILY
  • Mediator complex subunit 20 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may regulate transcription of class II genes through its association with RNA polymerase II-SRB complex (DNA dependent activity)
  • coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors
  • MED20 and MAF1 function in parallel pathways to negatively regulate ribosomal protein mRNA and tRNA synthesis
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNA polymerase II binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS