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FLASH GENE
Symbol SLC9A9 contributors: mct - updated : 28-06-2013
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 9
HGNC id 20653
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane domains
  • a binding region delineated to the central region of the C terminus
    • HOMOLOGY
    intraspecies homolog to SLC9A6,SLC9A7
    Homologene
    FAMILY
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text in late recycling endosomes
    basic FUNCTION
  • may be playing a role in neuronal cell function
  • potentially implicated in human attention deficit/hyperactivity disorder (ADHD), autism
  • membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RACK1 (receptor for activated C kinase 1), a cytoplasmic scaffold protein
  • interactions of SLC9A9 with two molecules: calcineurin homologous protein (CHP1) and receptor for activated C-kinase 1 (RACK1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS16
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS