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FLASH GENE
Symbol SLC9A9 contributors: mct - updated : 28-06-2013
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 9
HGNC id 20653
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrainlimbic systemhippocampus highly Homo sapiens
 brainhindbrainmedulla oblongata highlyHomo sapiens
 brainbasal nucleistriatum   Homo sapiens
 brainforebraincerebral cortex highly Homo sapiens
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text brain, heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ten transmembrane domains
  • a binding region delineated to the central region of the C terminus
    • HOMOLOGY
    intraspecies homolog to SLC9A6,SLC9A7
    Homologene
    FAMILY
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text in late recycling endosomes
    basic FUNCTION
  • may be playing a role in neuronal cell function
  • potentially implicated in human attention deficit/hyperactivity disorder (ADHD), autism
  • membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RACK1 (receptor for activated C kinase 1), a cytoplasmic scaffold protein
  • interactions of SLC9A9 with two molecules: calcineurin homologous protein (CHP1) and receptor for activated C-kinase 1 (RACK1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS16
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS