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FLASH GENE
Symbol SLC9A9 contributors: mct - updated : 28-06-2013
HGNC name solute carrier family 9 (sodium/hydrogen exchanger), member 9
HGNC id 20653
Corresponding disease
AUTS16 autism spectrum disorder, 13
Location 3q24      Physical location : 142.984.064 - 143.567.373
Synonym name
  • solute carrier family 9 (sodium/hydrogen exchanger), isoform 9
  • sodium/proton exchanger NHE9
  • putative protein product of Nbla00118
  • Na(+)/H(+) exchanger 9
    • Synonym symbol(s) FLJ35613, NHE9, Nbla00118
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 583.28 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3647 - 645 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunespleen   highly
     thymus   highly
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
     brainhindbrainmedulla oblongata highlyHomo sapiens
     brainbasal nucleistriatum   Homo sapiens
     brainforebraincerebral cortex highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text brain, heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane domains
  • a binding region delineated to the central region of the C terminus
    • HOMOLOGY
    intraspecies homolog to SLC9A6,SLC9A7
    Homologene
    FAMILY
  • monovalent cation:proton antiporter 1 (CPA1) transporter family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text in late recycling endosomes
    basic FUNCTION
  • may be playing a role in neuronal cell function
  • potentially implicated in human attention deficit/hyperactivity disorder (ADHD), autism
  • membrane protein that regulates the luminal pH of the recycling endosome, an essential organelle for synaptic transmission and plasticity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with RACK1 (receptor for activated C kinase 1), a cytoplasmic scaffold protein
  • interactions of SLC9A9 with two molecules: calcineurin homologous protein (CHP1) and receptor for activated C-kinase 1 (RACK1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS16
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS