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FLASH GENE
Symbol PLXDC1 contributors: SGE - updated : 26-03-2010
HGNC name plexin domain containing 1
HGNC id 20945
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a plexin-like domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Plxdc1 (82.0pc)
    homolog to rattus Plxdc1 (82.6pc)
    Homologene
    FAMILY plexin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text secreted
    basic FUNCTION
  • having receptor activity
  • may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the fibrovascular membranes (Yamaji 2008)
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    angiogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may interact with corctactin CTTN (Nanda 2004)
  • interacting with nidogen (Lee 2006)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in osteogenic sarcoma (Fuchs 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (Yamaji 2008)
  • elevated expression is associated with metastasis and poor survival of pateints with osteogenic sarcoma and may be a therapeutic target (Fuchs 2007)
    • ANIMAL & CELL MODELS