Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PLXDC1

contributors: SGE - updated : 26-03-2010

HGNC name	plexin domain containing 1
HGNC id	20945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q12      Physical location : 37.219.555 - 37.307.902
Synonym name	tumor endothelial marker 3
	tumor endothelial marker 7
Synonym symbol(s)	TEM3, TEM7, FLJ36270, FLJ45632, DKFZp686F0937

DNA

TYPE	functioning gene
STRUCTURE	88.35 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	produces four alternatively spliced transcripts with distinct functional domains (Halder 2009)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020405 14 - 6271 NP_065138 - 500 - Carson-Walters (2001) precursor

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Nervous optic nerve

cell lineage
cell lines	endothelial cells from colorectal cancers and primary cancers of lung, liver, pancreas, breast and brain
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a plexin-like domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to murine Plxdc1 (82.0pc)
	homolog to rattus Plxdc1 (82.6pc)

Homologene

FAMILY

plexin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm
text	secreted

basic FUNCTION	having receptor activity
	may play a significant role in the proliferation and maintenance of neovascular endothelial cells in the fibrovascular membranes (Yamaji 2008)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

angiogenesis

a component

INTERACTION

DNA

RNA

small molecule

protein	may interact with corctactin CTTN (Nanda 2004)
	interacting with nidogen (Lee 2006)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   highly expressed in osteogenic sarcoma (Fuchs 2007)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	may be a molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy (Yamaji 2008)
	elevated expression is associated with metastasis and poor survival of pateints with osteogenic sarcoma and may be a therapeutic target (Fuchs 2007)

ANIMAL & CELL MODELS