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FLASH GENE
Symbol RAD23B contributors: mct - updated : 07-04-2015
HGNC name RAD23 homolog B (S. cerevisiae)
HGNC id 9813
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one stress-inducible phosphoprotein (STI) binding domain
  • one xeroderma pigmentosum group C protein (XPC) binding domain
  • two Ubiquitin Associated (UBA) domains
  • one ubiquitin-like domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Rad23b (91.91 pc)
    homolog to murine Rad23b (91.67 pc)
    Homologene
    FAMILY
  • RAD23 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be involved in the ubiquitin mediated proteolytic pathway in cells
  • have redundant roles in DNA repair
  • maybe playing a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes
    • CELLULAR PROCESS nucleotide, repair, nucleotide excision repair
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a 125 kda subunit (p125) and of a 58 kda subunit (p58). interacts with MJD
  • forms a strong heterotrimeric complex with XPC and centrin 2 (CETN2) (Miron 2008)
    • INTERACTION
    DNA
  • single-stranded DNA binding
    • RNA
    small molecule
    protein
  • interaction with MJD
  • 26S proteasome
  • NGLY1
  • interacting with XPC, to recognize DNA damage in global genomic repair
  • RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS