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FLASH GENE

Symbol

RAD23B

contributors: mct - updated : 07-04-2015

HGNC name	RAD23 homolog B (S. cerevisiae)
HGNC id	9813

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately   vessel       moderately Digestive mouth       moderately Endocrine neuroendocrine pituitary     moderately   thyroid       moderately Hearing/Equilibrium ear inner cochlea   moderately Nervous nerve cranial nerve     highly Reproductive female system uterus     moderately   female system placenta     moderately   female system breast mammary gland   highly Respiratory lung       highly Skin/Tegument skin       moderately Urinary bladder       highly Visual eye lens     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective       moderately Connective adipose     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	liver, umbilical cord, embryonic tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one stress-inducible phosphoprotein (STI) binding domain
	one xeroderma pigmentosum group C protein (XPC) binding domain
	two Ubiquitin Associated (UBA) domains
	one ubiquitin-like domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Rad23b (91.91 pc)
	homolog to murine Rad23b (91.67 pc)

Homologene

FAMILY

RAD23 family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	may be involved in the ubiquitin mediated proteolytic pathway in cells
	have redundant roles in DNA repair
	maybe playing a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes

CELLULAR PROCESS	nucleotide, repair, nucleotide excision repair
	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimer of a 125 kda subunit (p125) and of a 58 kda subunit (p58). interacts with MJD
	forms a strong heterotrimeric complex with XPC and centrin 2 (CETN2) (Miron 2008)

INTERACTION

DNA	single-stranded DNA binding

RNA

small molecule

protein	interaction with MJD
	26S proteasome
	NGLY1
	interacting with XPC, to recognize DNA damage in global genomic repair
	RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS