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FLASH GENE
Symbol RAD23B contributors: mct - updated : 07-04-2015
HGNC name RAD23 homolog B (S. cerevisiae)
HGNC id 9813
Location 9q31.2      Physical location : 110.045.543 - 110.094.469
Synonym name
  • RAD23 (S. cerevisiae) homolog B
  • XP-C repair complementing protein
  • XP-C repair complementing complex 58 kDa
    • Synonym symbol(s) P58, HR23B, HHR23B
    DNA
    TYPE functioning gene
    STRUCTURE 48.93 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4130 - 409 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   moderately
    Digestivemouth   moderately
    Endocrineneuroendocrinepituitary  moderately
     thyroid   moderately
    Hearing/Equilibriumearinnercochlea moderately
    Nervousnervecranial nerve  highly
    Reproductivefemale systemuterus  moderately
     female systemplacenta  moderately
     female systembreastmammary gland highly
    Respiratorylung   highly
    Skin/Tegumentskin   moderately
    Urinarybladder   highly
    Visualeyelens  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connective   moderately
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text liver, umbilical cord, embryonic tissue
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one stress-inducible phosphoprotein (STI) binding domain
  • one xeroderma pigmentosum group C protein (XPC) binding domain
  • two Ubiquitin Associated (UBA) domains
  • one ubiquitin-like domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Rad23b (91.91 pc)
    homolog to murine Rad23b (91.67 pc)
    Homologene
    FAMILY
  • RAD23 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may be involved in the ubiquitin mediated proteolytic pathway in cells
  • have redundant roles in DNA repair
  • maybe playing a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes
    • CELLULAR PROCESS nucleotide, repair, nucleotide excision repair
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer of a 125 kda subunit (p125) and of a 58 kda subunit (p58). interacts with MJD
  • forms a strong heterotrimeric complex with XPC and centrin 2 (CETN2) (Miron 2008)
    • INTERACTION
    DNA
  • single-stranded DNA binding
    • RNA
    small molecule
    protein
  • interaction with MJD
  • 26S proteasome
  • NGLY1
  • interacting with XPC, to recognize DNA damage in global genomic repair
  • RAD23A, RAD23B facilitate lesion recognition by XPC but do not participate in the downstream DNA repair process
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS