| basic FUNCTION
| may be promoting clustering and fusion of late endosomes and lysosomes |
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modulating the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway |
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regulating the balance of SMAD2 and SMAD3 signaling by localizing SMAD4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses |
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TBC1D15 and and VPS39 regulate lysosomal morphology and play a role in maintaining growth factor dependence  |
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with TGFBRAP1, are nonredundant and essentially |
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required for early embryonic development |
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cytoplasmic protein involved in lysosomal processing as a novel interactor with Merkel cell polyomavirus large T (LT) oncoprotein |
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both VPS41 and VPS39 are required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes in human cells |
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is a novel player in ethanolamine-stimulated phosphatidylethanolamine (PE) transport to the mitochondria |
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acts as a negative regulator of ciliogenesis in human renal cells, by controlling the localization of the intraflagellar transport 20 protein at the base of cilia through autophagy |
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is an important regulator of myoblast differentiation and muscle glucose uptake |
