basic FUNCTION
| may be promoting clustering and fusion of late endosomes and lysosomes |
|
modulating the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway |
|
regulating the balance of SMAD2 and SMAD3 signaling by localizing SMAD4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses |
|
TBC1D15 and and VPS39 regulate lysosomal morphology and play a role in maintaining growth factor dependence ![](pubmed.jpg) |
|
with TGFBRAP1, are nonredundant and essentially |
|
required for early embryonic development ![](pubmed.jpg) |
|
cytoplasmic protein involved in lysosomal processing as a novel interactor with Merkel cell polyomavirus large T (LT) oncoprotein ![](pubmed.jpg) |
|
both VPS41 and VPS39 are required for late endosomal-lysosomal fusion events and the delivery of endocytic cargo to lysosomes in human cells ![](pubmed.jpg) |
|
is a novel player in ethanolamine-stimulated phosphatidylethanolamine (PE) transport to the mitochondria ![](pubmed.jpg) |
|
acts as a negative regulator of ciliogenesis in human renal cells, by controlling the localization of the intraflagellar transport 20 protein at the base of cilia through autophagy ![](pubmed.jpg) |
|
is an important regulator of myoblast differentiation and muscle glucose uptake ![](pubmed.jpg) |