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FLASH GENE
Symbol VPS39 contributors: mct - updated : 30-08-2011
HGNC name vacuolar protein sorting 39 (yeast)
HGNC id 20593
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to TRAP1
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,organelle,lysosome
basic FUNCTION
  • may be promoting clustering and fusion of late endosomes and lysosomes
  • modulating the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway
  • regulating the balance of SMAD2 and SMAD3 signaling by localizing SMAD4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses
  • TBC1D15 and and VPS39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
  • with TGFBRAP1, are nonredundant and essentially
  • required for early embryonic development
  • cytoplasmic protein involved in lysosomal processing as a novel interactor with Merkel cell polyomavirus large T (LT) oncoprotein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS