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FLASH GENE
Symbol IL22RA2 contributors: mct - updated : 09-04-2019
HGNC name interleukin 22 receptor, alpha 2
HGNC id 14901
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one signal peptide
  • four cysteine conserved among members of the class II cytokine receptor family
  • five potential N-linked glycosylation sites
    • HOMOLOGY
    intraspecies homolog to IL22R1
    IL1OR
    Homologene
    FAMILY claa II cytokine receptor family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing an important role as an IL22 antagonist in the regulation of inflammatory response
  • plays a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon
  • IL22 and IL22RA2 are regulated during intestinal tissue damage
  • promotes bacterial uptake into Peyer patches (PPs) by influencing follicle-associated epithelium (FAE) gene expression and function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL22 (blocking its interaction with cell surface IL22R complex)
  • regulation of IL22RA2 is crucial to control the effects of IL22 during intestinal tissue damage and tumorigenesis
  • IL22RA2 is a soluble IL22 receptor, which antagonizes IL22 activity and has genetic associations with autoimmune diseases
    • cell & other
    REGULATION
    Other regulation of IL22RA2 via the inflammasome provides an unanticipated mechanism, controlling IL22 and thereby the development of colon cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    IL22RA2 is a new relevant therapeutic target in nflammatory bowel diseases (IBDs)
    ANIMAL & CELL MODELS