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FLASH GENE
Symbol IL22RA2 contributors: mct - updated : 09-04-2019
HGNC name interleukin 22 receptor, alpha 2
HGNC id 14901
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly Homo sapiens
Reproductivefemale systembreast   
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one signal peptide
  • four cysteine conserved among members of the class II cytokine receptor family
  • five potential N-linked glycosylation sites
  • HOMOLOGY
    intraspecies homolog to IL22R1
    IL1OR
    Homologene
    FAMILY claa II cytokine receptor family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing an important role as an IL22 antagonist in the regulation of inflammatory response
  • plays a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon
  • IL22 and IL22RA2 are regulated during intestinal tissue damage
  • promotes bacterial uptake into Peyer patches (PPs) by influencing follicle-associated epithelium (FAE) gene expression and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL22 (blocking its interaction with cell surface IL22R complex)
  • regulation of IL22RA2 is crucial to control the effects of IL22 during intestinal tissue damage and tumorigenesis
  • IL22RA2 is a soluble IL22 receptor, which antagonizes IL22 activity and has genetic associations with autoimmune diseases
  • cell & other
    REGULATION
    Other regulation of IL22RA2 via the inflammasome provides an unanticipated mechanism, controlling IL22 and thereby the development of colon cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    IL22RA2 is a new relevant therapeutic target in nflammatory bowel diseases (IBDs)
    ANIMAL & CELL MODELS