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FLASH GENE

Symbol

IL22RA2

contributors: mct - updated : 09-04-2019

HGNC name	interleukin 22 receptor, alpha 2
HGNC id	14901

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052962 7 - 2910 NP_443194 - 263 - 2016 27678220 variant 1, IL22BPi1 capable of neutralizing the biological activity of IL22 NM_181309 6 - 2814 NP_851826 - 231 - 2016 27678220 IL22BPi2 lacking a segment within the coding region leading to a frameshift capable of neutralizing the biological activity of IL22 NM_181310 5 - 2644 NP_851827 - 130 is largely retained in the endoplasmic reticulum (ER) 2016 27678220 variant 3, IL22BPi3 lacking two fragments in the coding region, leadind to a frameshift aénd a shurter isoform

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Homo sapiens Reproductive female system breast       Respiratory lung

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one signal peptide
	four cysteine conserved among members of the class II cytokine receptor family
	five potential N-linked glycosylation sites

HOMOLOGY

intraspecies	homolog to IL22R1
	IL1OR

Homologene

FAMILY

claa II cytokine receptor family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	playing an important role as an IL22 antagonist in the regulation of inflammatory response
	plays a crucial role in controlling tumorigenesis and epithelial cell proliferation in the colon
	IL22 and IL22RA2 are regulated during intestinal tissue damage
	promotes bacterial uptake into Peyer patches (PPs) by influencing follicle-associated epithelium (FAE) gene expression and function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	IL22 (blocking its interaction with cell surface IL22R complex)
	regulation of IL22RA2 is crucial to control the effects of IL22 during intestinal tissue damage and tumorigenesis
	IL22RA2 is a soluble IL22 receptor, which antagonizes IL22 activity and has genetic associations with autoimmune diseases

cell & other

REGULATION

Other

regulation of IL22RA2 via the inflammasome provides an unanticipated mechanism, controlling IL22 and thereby the development of colon cancer

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   IL22RA2 is a new relevant therapeutic target in nflammatory bowel diseases (IBDs)

ANIMAL & CELL MODELS