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FLASH GENE
Symbol KIF14 contributors: mct - updated : 17-09-2018
HGNC name kinesin family member 14
HGNC id 19181
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FHA domain
  • a kinesin motor domain
  • myosin tail
    • HOMOLOGY
    interspecies homolog to Drosophila Kinesin 73
    Homologene
    FAMILY kinesin-like protein family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • microtubule motor protein, localized at the midbody to finalize cytokinesis by interacting with CIT
    • basic FUNCTION
  • putative chromokinesin, important in oncogenesis, and having promise as a prognostic indicator and therapeutic target
  • mitotic kinesin gene playing an important role in cytokinesis
  • targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis
  • KIF14 is essential for the generation and maturation of late-developing structures such as the myelin sheath, cerebellar and cerebral cortices
  • is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers
  • binds tightly to microtubules and adopts a rigor-like conformation
  • mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis
  • can promote tumor formation in susceptible cells
  • could act as a potential oncogene that contributes to tumor progression and poor prognosis in Prostate carcinoma
  • can bind to, crosslink or slide microtubules and, thus, regulate microtubule organization and spindle assembly
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PRC1
  • KIF14 associates with the PDZ domain of RADIL and negatively regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules
  • SOX17 is negatively related to KIF14 expression in HCC tissue and SOX17 inhibits hepatocellular carcinoma (HCC) cell proliferation and migration by transcriptional downregulation of KIF14 expression
  • is a mitotic motor protein that is required for spindle localization of the mitotic citron rho-interacting kinase, CIT, also mutated in microcephaly
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH20 , MKS12
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in retinoblastoma tumors, primary retinoblastoma with an older age at diagnosis, breast and lung cancer
    tumoral     --over  
    associated with increased overall survival (OAS) of ovarian cancer patients
    tumoral     --over  
    in Medulloblastoma (MB) and is an adverse prognostic factor for survival
    tumoral     --over  
    of KIF14 and E2F3 protein in retinoblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a novel and useful prognostic biomarker for Prostate carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    potential therapeutic target for Medulloblastoma (MB)
    ANIMAL & CELL MODELS