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FLASH GENE
Symbol KIF14 contributors: mct - updated : 17-09-2018
HGNC name kinesin family member 14
HGNC id 19181
DNA
TYPE functioning gene
STRUCTURE 69.29 kb     30 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 7293 - 1648 - 2017 28892560
28 - 6881 - 1157 - 2017 28892560
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland highly
 male systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FHA domain
  • a kinesin motor domain
  • myosin tail
  • HOMOLOGY
    interspecies homolog to Drosophila Kinesin 73
    Homologene
    FAMILY kinesin-like protein family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • microtubule motor protein, localized at the midbody to finalize cytokinesis by interacting with CIT
  • basic FUNCTION
  • putative chromokinesin, important in oncogenesis, and having promise as a prognostic indicator and therapeutic target
  • mitotic kinesin gene playing an important role in cytokinesis
  • targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis
  • KIF14 is essential for the generation and maturation of late-developing structures such as the myelin sheath, cerebellar and cerebral cortices
  • is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers
  • binds tightly to microtubules and adopts a rigor-like conformation
  • mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis
  • can promote tumor formation in susceptible cells
  • could act as a potential oncogene that contributes to tumor progression and poor prognosis in Prostate carcinoma
  • can bind to, crosslink or slide microtubules and, thus, regulate microtubule organization and spindle assembly
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with PRC1
  • KIF14 associates with the PDZ domain of RADIL and negatively regulates RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules
  • SOX17 is negatively related to KIF14 expression in HCC tissue and SOX17 inhibits hepatocellular carcinoma (HCC) cell proliferation and migration by transcriptional downregulation of KIF14 expression
  • is a mitotic motor protein that is required for spindle localization of the mitotic citron rho-interacting kinase, CIT, also mutated in microcephaly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH20 , MKS12
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in retinoblastoma tumors, primary retinoblastoma with an older age at diagnosis, breast and lung cancer
    tumoral     --over  
    associated with increased overall survival (OAS) of ovarian cancer patients
    tumoral     --over  
    in Medulloblastoma (MB) and is an adverse prognostic factor for survival
    tumoral     --over  
    of KIF14 and E2F3 protein in retinoblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a novel and useful prognostic biomarker for Prostate carcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    potential therapeutic target for Medulloblastoma (MB)
    ANIMAL & CELL MODELS