basic FUNCTION
| putative chromokinesin, important in oncogenesis, and having promise as a prognostic indicator and therapeutic target |
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mitotic kinesin gene playing an important role in cytokinesis |
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targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis |
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KIF14 is essential for the generation and maturation of late-developing structures such as the myelin sheath, cerebellar and cerebral cortices |
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is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers |
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binds tightly to microtubules and adopts a rigor-like conformation |
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mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis |
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can promote tumor formation in susceptible cells |
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could act as a potential oncogene that contributes to tumor progression and poor prognosis in Prostate carcinoma |
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can bind to, crosslink or slide microtubules and, thus, regulate microtubule organization and spindle assembly |