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FLASH GENE
Symbol COG4 contributors: mct - updated : 25-10-2018
HGNC name component of oligomeric Golgi complex 4
HGNC id 18620
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal coiled-coil region
  • C-terminal domains forms a crucial salt bridge that anchors domain E to domain D (Koncarevic 2009)
    • mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Cog4
    Homologene
    FAMILY
  • COG4 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a critical role for the structure and function of the Golgi apparatus and influencing intracellular membrane trafficking
  • required to maintain Golgi dynamics and its associated functions (Reynders 2009)
  • role for COG4 in inner ear development and skeletogenesis, associated with defective Golgi structure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SCFD1 (Laufman 2009)
  • COG4-STX5 interactions (COG4 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2J , SWILS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS