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FLASH GENE
Symbol COG4 contributors: mct - updated : 25-10-2018
HGNC name component of oligomeric Golgi complex 4
HGNC id 18620
Corresponding disease
CDG2J congenital disorder of glycosylation, type IIJ
SWILS Saul-Wilson syndrome
Location 16q22.1      Physical location : 70.514.472 - 70.557.457
Synonym name
  • complexed with Dor1p
  • conserved oligomeric Golgi complex component 4
  • Synonym symbol(s) COD1, DKFZp586E1519
    DNA
    TYPE functioning gene
    STRUCTURE 42.99 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 2838 - 789 - Ungar (2002)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    Visualeyelens   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal coiled-coil region
  • C-terminal domains forms a crucial salt bridge that anchors domain E to domain D (Koncarevic 2009)
  • mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Cog4
    Homologene
    FAMILY
  • COG4 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • playing a critical role for the structure and function of the Golgi apparatus and influencing intracellular membrane trafficking
  • required to maintain Golgi dynamics and its associated functions (Reynders 2009)
  • role for COG4 in inner ear development and skeletogenesis, associated with defective Golgi structure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the conserved oligomeric golgi complex which is composed of eight different subunits
  • COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
  • COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SCFD1 (Laufman 2009)
  • COG4-STX5 interactions (COG4 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2J , SWILS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS