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FLASH GENE

Symbol

COG4

contributors: mct - updated : 25-10-2018

HGNC name	component of oligomeric Golgi complex 4
HGNC id	18620

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015386 19 - 2838 NP_056201 - 789 - Ungar (2002)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Nervous brain         Respiratory lung         Urinary kidney         Visual eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal coiled-coil region
	C-terminal domains forms a crucial salt bridge that anchors domain E to domain D (Koncarevic 2009)

mono polymer

heteromer , oligo

HOMOLOGY

interspecies

ortholog to murine Cog4

Homologene

FAMILY

COG4 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	playing a critical role for the structure and function of the Golgi apparatus and influencing intracellular membrane trafficking
	required to maintain Golgi dynamics and its associated functions (Reynders 2009)
	role for COG4 in inner ear development and skeletogenesis, associated with defective Golgi structure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the conserved oligomeric golgi complex which is composed of eight different subunits
	COG complex essentially formed by two subcomplexes, lobe A (COG1-4) and lobe B (COG5-8)
	COG1, COG2, COG3, COG4, form a stable core complex potentially sufficient to support wild-type growth and reasonably efficient retrograde trafficking

INTERACTION

DNA

RNA

small molecule

protein	interacting with SCFD1 (Laufman 2009)
	COG4-STX5 interactions (COG4 protein initiate the formation of two different tethering platforms that can facilitate the redirection of two populations of Golgi transport intermediates to the mitochondrial vicinity)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG2J , SWILS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS