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FLASH GENE
Symbol NXNL2 contributors: mct - updated : 22-12-2015
HGNC name nucleoredoxin-like 2
HGNC id 30482
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine 1110018J18Rik
homolog to rattus Rn.24906
intraspecies paralog to NXNL1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons
  • clock- and light-dependent regulations of NXNL1, NXNL2 that may be part of a protective shield against photooxidative damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualretina
    major therapeutic potential for human retinal neurodegenerative diseases such as retinitis pigmentosa
    ANIMAL & CELL MODELS
  • Nxnl2-/- mice present a stronger age-dependent impairment of fine odor discrimination