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FLASH GENE

Symbol

NXNL2

contributors: mct - updated : 22-12-2015

HGNC name	nucleoredoxin-like 2
HGNC id	30482

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	49.39 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145283 3 - 1496 NP_660326 - 135 expressed by rods 2012 22343139 RdCVF2L possess an entire thioredoxin fold is involved in maintenance of outer segment may act in the transport of rhodopsin protein to the outer segments of rod cells is able to reduce TAU phosphorylation, as does RdCVFL, but does not protect the rod from light damage NM_001161625 2 - 805 NP_001155097 - 156 expressed by rods 2012 22343139 RdCVF2 trophic factor whose action is relayed by the activation of an as yet unidentified cell surface receptor that mediates a cascade of events leading to the survival of the target cells is necessary for neuronal survival exhibits cone rescue activity that is independent of its putative thiol-oxydoreductase activity

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Olfactory (smell) olfactory bulb         Homo sapiens Visual eye retina     specific Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Visual cone photoreceptor Homo sapiens Visual rod photoreceptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine 1110018J18Rik
	homolog to rattus Rn.24906

intraspecies

paralog to NXNL1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons
	clock- and light-dependent regulations of NXNL1, NXNL2 that may be part of a protective shield against photooxidative damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual retina major therapeutic potential for human retinal neurodegenerative diseases such as retinitis pigmentosa

ANIMAL & CELL MODELS

Nxnl2-/- mice present a stronger age-dependent impairment of fine odor discrimination