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FLASH GENE
Symbol NXNL2 contributors: mct - updated : 22-12-2015
HGNC name nucleoredoxin-like 2
HGNC id 30482
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Olfactory (smell)olfactory bulb     Homo sapiens
Visualeyeretina  specific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine 1110018J18Rik
homolog to rattus Rn.24906
intraspecies paralog to NXNL1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • bi-functional gene involved in the maintenance of both the function and the viability of sensory neurons
  • clock- and light-dependent regulations of NXNL1, NXNL2 that may be part of a protective shield against photooxidative damage
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisualretina
    major therapeutic potential for human retinal neurodegenerative diseases such as retinitis pigmentosa
    ANIMAL & CELL MODELS
  • Nxnl2-/- mice present a stronger age-dependent impairment of fine odor discrimination