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FLASH GENE
Symbol ANAPC11 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 11
HGNC id 14452
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RING-H2 type zinc finger motif
  • HOMOLOGY
    interspecies homolog to murine Anapc11
    homolog to yeast Apc11p
    intraspecies homolog to RNF7
    Homologene
    FAMILY
  • RING-box family
  • APC (anaphase promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text
  • regulating the onset of sister chromatid separation and exit of mitosis
  • mediating the ubiquitination of the securin protein(PTTG1) and mitotic cyclins
  • PATHWAY
    metabolism
    signaling
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding UBC4 and C terminal cullin homology domain of APC2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS