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FLASH GENE

Symbol

ANAPC11

contributors: mct - updated : 03-09-2010

HGNC name	anaphase promoting complex subunit 11
HGNC id	14452

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.3      Physical location : 79.849.598 - 79.858.363
Synonym name	hepatocellular carcinoma associated ring finger family
	APC11 anaphase promoting complex subunit 11 homolog (yeast)
	cyclosome subunit 11
Synonym symbol(s)	APC11, APC11P, HSPC214, MGC882

DNA

TYPE	functioning gene
STRUCTURE	8.77 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001002244 4 - 1130 NP_001002244 - 196 - Chan (2001) NM_001002245 3 - 799 NP_001002245 - 84 - Chan (2001) NM_001002246 4 - 862 NP_001002246 - 84 - Chan (2001) NM_001002247 3 - 807 NP_001002247 - 84 - Chan (2001) NM_001002248 4 - 870 NP_001002248 - 84 - Chan (2001) NM_001002249 4 - 916 NP_001002249 - 84 - Chan (2001) NM_016476 4 - 892 NP_057560 - 84 - Chan (2001)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine pancreas       highly Nervous brain forebrain cerebral lobe frontal   Reproductive male system prostate       Respiratory lung       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one RING-H2 type zinc finger motif

HOMOLOGY

interspecies	homolog to murine Anapc11
	homolog to yeast Apc11p

intraspecies

homolog to RNF7

Homologene

FAMILY	RING-box family
	APC (anaphase promoting complex) family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
	orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)

CELLULAR PROCESS	cell cycle, division, mitosis
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

text	regulating the onset of sister chromatid separation and exit of mitosis
	mediating the ubiquitination of the securin protein(PTTG1) and mitotic cyclins

PATHWAY

metabolism

signaling

a component

member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

binding UBC4 and C terminal cullin homology domain of APC2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS