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FLASH GENE
Symbol ANAPC11 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 11
HGNC id 14452
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1130 - 196 - Chan (2001)
3 - 799 - 84 - Chan (2001)
4 - 862 - 84 - Chan (2001)
3 - 807 - 84 - Chan (2001)
4 - 870 - 84 - Chan (2001)
4 - 916 - 84 - Chan (2001)
4 - 892 - 84 - Chan (2001)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
Nervousbrainforebraincerebral lobefrontal 
Reproductivemale systemprostate   
Respiratorylung   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RING-H2 type zinc finger motif
  • HOMOLOGY
    interspecies homolog to murine Anapc11
    homolog to yeast Apc11p
    intraspecies homolog to RNF7
    Homologene
    FAMILY
  • RING-box family
  • APC (anaphase promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text
  • regulating the onset of sister chromatid separation and exit of mitosis
  • mediating the ubiquitination of the securin protein(PTTG1) and mitotic cyclins
  • PATHWAY
    metabolism
    signaling
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding UBC4 and C terminal cullin homology domain of APC2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS