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FLASH GENE
Symbol DHPS contributors: mct/npt - updated : 13-03-2019
HGNC name deoxyhypusine synthase
HGNC id 2869
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
  • deoxyhypusine synthase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • deoxyhypusine synthase, required for the post-translational formation of hypusine an unusual amino acid formed lysine from by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA)
  • playing a pivotal role in cell proliferation
  • EIF5A protein and DHPS modification are essential for eukaryotic cell proliferation (Park 2006)
  • DHPS promotes early cytokine-induced inflammation in the pancreatic beta cells
  • WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3 prime untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation
  • catalyzes the crucial hypusine modification of the factor EIF5A, which promotes the translation of a subset of mRNAs involved in cytokine responses
  • functions as a tetramer to catalyze the initial step, transferring the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue (Lys50 in human EIF5A) of EIF5A, thereby forming the intermediate deoxyhypusine residue
    • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NAD+
    • protein
  • hypusination by DHPS is required for the ongoing production of proteins, particularly DDIT3, in response to ER stress in the beta cell
  • role for DHPS (and hypusinated EIF5A) in cellular stress responses
  • essential nature of both EIF5A and DHPS in mammalian development
  • role for DHPS in promoting T cell proliferation and differentiation via regulation of IL2RA
  • hypusine modification in EIF5A is crucial for homeostasis in mammals
  • DHPS-mediated hypusine-modification of EIF5A facilitated the translation of RHOA, resulting in the activation of the RHOA signaling pathway and leading to not only increased cell motility, and also increased tumor growth
  • DHPS catalyzes the hypusination of EIF5A using the butylamine moiety of spermidine via NAD-dependent oxidative reaction
  • DHPS or DOHH, are both involved in hypusination of EIF5A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DHPSD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dhps-null mice are embryonic lethal