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FLASH GENE

Symbol

DHPS

contributors: mct/npt - updated : 13-03-2019

HGNC name	deoxyhypusine synthase
HGNC id	2869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Lymphoid/Immune spleen       highly   thymus       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

tetramer

HOMOLOGY

Homologene

FAMILY

deoxyhypusine synthase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	deoxyhypusine synthase, required for the post-translational formation of hypusine an unusual amino acid formed lysine from by modification of a specific residue in eucaryotic initiation factor 5A (EI5FA)
	playing a pivotal role in cell proliferation
	EIF5A protein and DHPS modification are essential for eukaryotic cell proliferation (Park 2006)
	DHPS promotes early cytokine-induced inflammation in the pancreatic beta cells
	WDR83 and DHPS were capable of forming an RNA duplex at overlapping 3 prime untranslated regions and this duplex increased their mutual stability, which was required for the bidirectional regulation
	catalyzes the crucial hypusine modification of the factor EIF5A, which promotes the translation of a subset of mRNAs involved in cytokine responses
	functions as a tetramer to catalyze the initial step, transferring the 4-aminobutyl moiety from the polyamine spermidine to a specific lysine residue (Lys50 in human EIF5A) of EIF5A, thereby forming the intermediate deoxyhypusine residue

CELLULAR PROCESS	cell cycle
	cell life, proliferation/growth
	protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NAD+

protein	hypusination by DHPS is required for the ongoing production of proteins, particularly DDIT3, in response to ER stress in the beta cell
	role for DHPS (and hypusinated EIF5A) in cellular stress responses
	essential nature of both EIF5A and DHPS in mammalian development
	role for DHPS in promoting T cell proliferation and differentiation via regulation of IL2RA
	hypusine modification in EIF5A is crucial for homeostasis in mammals
	DHPS-mediated hypusine-modification of EIF5A facilitated the translation of RHOA, resulting in the activation of the RHOA signaling pathway and leading to not only increased cell motility, and also increased tumor growth
	DHPS catalyzes the hypusination of EIF5A using the butylamine moiety of spermidine via NAD-dependent oxidative reaction
	DHPS or DOHH, are both involved in hypusination of EIF5A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DHPSD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Dhps-null mice are embryonic lethal