protein
| hypusination by DHPS is required for the ongoing production of proteins, particularly DDIT3, in response to ER stress in the beta cell |
|
role for DHPS (and hypusinated EIF5A) in cellular stress responses |
|
essential nature of both EIF5A and DHPS in mammalian development |
|
role for DHPS in promoting T cell proliferation and differentiation via regulation of IL2RA |
|
hypusine modification in EIF5A is crucial for homeostasis in mammals |
|
DHPS-mediated hypusine-modification of EIF5A facilitated the translation of RHOA, resulting in the activation of the RHOA signaling pathway and leading to not only increased cell motility, and also increased tumor growth |
|
DHPS catalyzes the hypusination of EIF5A using the butylamine moiety of spermidine via NAD-dependent oxidative reaction |
|
DHPS or DOHH, are both involved in hypusination of EIF5A |