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FLASH GENE
Symbol RAB6B contributors: mct/npt - updated : 25-01-2017
HGNC name RAB6B, member RAS oncogene family
HGNC id 14902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
    • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text with BICD1 co-localize at the Golgi and vesicles that align along microtubules
    basic FUNCTION
  • small GTPase playing a potential specific role in retrograde membrane traffic
  • playing a regulatory role in the retrograde transport of cargo in neuronal cells, via its interaction with BICD1
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIF1, other RAB6A effectors
  • with BICD1
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • GDAP1 interacts with the vesicle-organelle trafficking proteins RAB6B, suggesting that GDAP1 may participate in the mitochondrial movement within the cell
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS