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FLASH GENE
Symbol RAB6B contributors: mct/npt - updated : 25-01-2017
HGNC name RAB6B, member RAS oncogene family
HGNC id 14902
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
Nervousbrain   predominantly
 nerve   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
cell lineage
cell lines neuroblastoma cell lines SK-N-SH
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text with BICD1 co-localize at the Golgi and vesicles that align along microtubules
    basic FUNCTION
  • small GTPase playing a potential specific role in retrograde membrane traffic
  • playing a regulatory role in the retrograde transport of cargo in neuronal cells, via its interaction with BICD1
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIF1, other RAB6A effectors
  • with BICD1
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • GDAP1 interacts with the vesicle-organelle trafficking proteins RAB6B, suggesting that GDAP1 may participate in the mitochondrial movement within the cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS