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FLASH GENE
Symbol RAB6B contributors: mct/npt - updated : 25-01-2017
HGNC name RAB6B, member RAS oncogene family
HGNC id 14902
DNA
TYPE functioning gene
STRUCTURE 71.61 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5561 23.3 208 - Wanschers (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Hearing/Equilibriumear   highly
Nervousbrain   predominantly
 nerve   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
cell lineage
cell lines neuroblastoma cell lines SK-N-SH
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text with BICD1 co-localize at the Golgi and vesicles that align along microtubules
    basic FUNCTION
  • small GTPase playing a potential specific role in retrograde membrane traffic
  • playing a regulatory role in the retrograde transport of cargo in neuronal cells, via its interaction with BICD1
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIF1, other RAB6A effectors
  • with BICD1
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • PADI2 regulates the expression of the TNFRSF1B, ADAMTS9, and RAB6B transcripts in mast cells
  • GDAP1 interacts with the vesicle-organelle trafficking proteins RAB6B, suggesting that GDAP1 may participate in the mitochondrial movement within the cell
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS