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FLASH GENE
Symbol NAXE contributors: mct - updated : 16-11-2016
HGNC name NAD(P)HX epimerase [Homo sapiens]
HGNC id 18453
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide for translocation into the endoplasmic reticulum
  • a putative signal sequence cleavage site, export-directing signal
  • several putative phosphorylation
  • O-glycosylation site
    • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • YjeF_N family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • important role in the renal tubular degradation or resorption of APOA1
  • plays an important role in sperm capacitation possibly providing a link between protein phosphorylation and cholesterol efflux
  • secreted NAXE positively regulates cholesterol efflux from endothelial cells and effective cholesterol efflux is critical for proper angiogenesis
  • encodes two different proteins, which we show to be targeted to the mitochondria (mAIBP) and the cytosol (cAIBP)
  • contributes to mitotic entry and bipolar spindle assembly and may partially control localization, phosphorylation, and activation of both AURKA and PLK1 via NIN during mitotic progression
  • catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites
  • epimerase essential in the cellular metabolite repair for NADHX and NADPHX
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with apolipoprotein A1, the component of high-density lipoprotein involved in cholesterol transport
  • acts not only as a substrate but also as a positive regulator of both AURKA and PLK1
  • functions as a negative regulator to block phosphorylation of NIN1 mediated by AURKA and PLK1
    • cell & other
    REGULATION
    Other phosphorylated downstream to PKA activation, and localizes to both sperm head and tail domains
    ASSOCIATED DISORDERS
    corresponding disease(s) NAXED
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS