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FLASH GENE

Symbol

NAXE

contributors: mct - updated : 16-11-2016

HGNC name	NAD(P)HX epimerase [Homo sapiens]
HGNC id	18453

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144772 6 - 1121 NP_658985 29.1 288 - 2002 11991719

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine adrenal gland       highly   thyroid       highly Reproductive male system testis     highly Urinary kidney nephron     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum cardiac

cells

System Cell Pubmed Species Stage Rna symbol Reproductive sperm cell Urinary tubular cell

cell lineage
cell lines
fluid/secretion	in cerebrospinal fluid and urine

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal peptide for translocation into the endoplasmic reticulum
	a putative signal sequence cleavage site, export-directing signal
	several putative phosphorylation
	O-glycosylation site

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

YjeF_N family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule
	intracellular,nucleus,nucleoplasm

basic FUNCTION	important role in the renal tubular degradation or resorption of APOA1
	plays an important role in sperm capacitation possibly providing a link between protein phosphorylation and cholesterol efflux
	secreted NAXE positively regulates cholesterol efflux from endothelial cells and effective cholesterol efflux is critical for proper angiogenesis
	encodes two different proteins, which we show to be targeted to the mitochondria (mAIBP) and the cytosol (cAIBP)
	contributes to mitotic entry and bipolar spindle assembly and may partially control localization, phosphorylation, and activation of both AURKA and PLK1 via NIN during mitotic progression
	catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites
	epimerase essential in the cellular metabolite repair for NADHX and NADPHX

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with apolipoprotein A1, the component of high-density lipoprotein involved in cholesterol transport
	acts not only as a substrate but also as a positive regulator of both AURKA and PLK1
	functions as a negative regulator to block phosphorylation of NIN1 mediated by AURKA and PLK1

cell & other

REGULATION

Other

phosphorylated downstream to PKA activation, and localizes to both sperm head and tail domains

ASSOCIATED DISORDERS

corresponding disease(s)

NAXED

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS