Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol B3GNT2 contributors: mct - updated : 28-01-2014
HGNC name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
HGNC id 15629
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three conserved cysteine residues
  • an N terminal cytoplasmic domain
  • a transmembrane segment,a stem region
  • a catalytic domain with five potential N glycosylation sites
    • HOMOLOGY
    interspecies homolog to murine B3gnt1
    intraspecies homolog to B3GNT3,B3GNT4
    Homologene
    FAMILY
  • beta-1,3-N-acetylglucosaminyltransferase family
  • glycosyltransferase 31 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • protein glycosylation
  • novel function for B3GNT2 glycosylation in maintaining expression of layer-specific vomeronasal receptors, as well as adhesion molecules required for proper accessory olfactory bulb (AOB) glomerular formation
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    biosynthesis of poly-N-acetylactosamine chains
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GCNT2 functions together with B3GNT2 to determine Poly-N-acetyllactosamine(PLN) levels in olfactory neurons by regulating beta1,6-branches that promote PLN extension
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • hyperactivation of lymphocytes occurred due to a lack of polylactosamine on receptor molecules in B3gnt2-/- mice